Can CoQ10 help with AFib

Cardiac arrhythmias: naturally strengthening the heart with micronutrient medicine

Albert, C.M. et al. (2012): Omega-3 fatty acids, ventricular arrhythmias, and sudden cardiac death: antiarrhythmic, proarrhythmic or neither. Circ Arrhythm Electrophysiol 2012; 5 (3): 456-59. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399517/pdf/nihms385378.pdf, accessed on: May 3, 2019.

Abdelhamid, A.S. et al. (2018): Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease. Cochrane Database Syst Rev 2018 Nov 30; 11: CD003177. https://www.ncbi.nlm.nih.gov/pubmed/30521670, accessed on: May 3, 2019.

Aburto, N.J. et al. (2013): Effect of increased potassium intake on cardiovascular risk factors and disease: systematic review and meta-analyze. BMJ 2013; 346 f1378. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816263/, accessed on: May 3, 2019.

Baker, W.L. (2017): Treating arrhythmias with acute adjunctive magnesium: identifying future research directions. Eur Heart J Cardiovasc Pharmacother 2017 Apr 1; ​​3 (2): 108-117. https://www.ncbi.nlm.nih.gov/pubmed/27634841, accessed on: May 3, 2019.

Behmanesh, S. et al. (2006): Effect of prophylactic bisoprolol plus magnesium on the incidence of atrial fibrillation after coronary bypass surgery: results of a randomized controlled trial. Curr Med Res Opin 2006 Aug; 22 (8): 1443-50. https://www.ncbi.nlm.nih.gov/pubmed/16870070, accessed on: May 3, 2019.

Bigg, R.P. (1981): Magnesium deficiency. Role in arrhythmias complicating acute myocardial infarction? Med J Aust 1981 Apr 4; 1 (7): 346-8. https://www.ncbi.nlm.nih.gov/pubmed/7242415, accessed on: May 3, 2019.

Brouwer, I.A. et al. (2006): Intake of very long-chain n-3 fatty acids from fish and incidence of atrial fibrillation. The Rotterdam Study. Am Heart J 2006 Apr; 151 (4): 857-62. https://www.ncbi.nlm.nih.gov/pubmed/16569549, accessed on: May 3, 2019.

Cekic, S. et al. (2010): The effect of vitamin C on amiodarone-induced toxicity in rat thymocytes. Cent Eur J Med 2010; 6 (1): 58-63. https://www.degruyter.com/downloadpdf/j/med.2011.6.issue-1/s11536-010-0050-5/s11536-010-0050-5.pdf, accessed on: May 3, 2019.

Cheng, J.W. et al. (2008): Omega-3 fatty acid: a role in the management of cardiac arrhythmias? J Altern Complement Med 2008 Oct; 14 (8): 965-74. https://www.ncbi.nlm.nih.gov/pubmed/18928392, accessed on: May 3, 2019.

Chung, M.K. (2004): Vitamins, supplements, herbal medicines, and arrhythmias. Cardiol Rev 2004 Mar-Apr; 12 (2): 73-84. https://www.ncbi.nlm.nih.gov/pubmed/14766022, accessed on: May 3, 2019.

Cook, R.C. et al. (2009): Prophylactic intravenous magnesium sulphate in addition to oral (beta) -blockade does not prevent atrial arrhythmias after coronary artery or valvular heart surgery: a randomized, controlled trial. Circulation 2009 Sep 15; 120 (11 Suppl): S163-9. https://www.ncbi.nlm.nih.gov/pubmed/19752363, accessed on: May 3, 2019.

Coronel, R. et al. (2017): The pro or antiarrhythmic actions of polyunsaturated fatty acids and cholesterol. Pharmacol Ther. 2017 Aug; 176: 40-47. https://www.ncbi.nlm.nih.gov/pubmed/28167219, accessed on: May 3, 2019.

Dambrova, M. et al. (2016): Diabetes is associated with higher trimethylamine n-oxide plasma levels. Exp Clin Endocrinol Diabetes 2016 Apr; 124 (4): 251-6. https://www.ncbi.nlm.nih.gov/pubmed/27123785, accessed on: May 3, 2019.

Dastan, F. et al. (2018): Randomized trial of carnitine for the prevention of perioperative atrial fibrillation. Semin Thorac Cardiovasc Surg 2018 Spring; 30 (1): 7-13. https://www.ncbi.nlm.nih.gov/pubmed/28982550, accessed on: May 3, 2019.

Den Ruijter, H.M. et al. (2007): Pro- and antiarrhythmic properties of a diet rich in fish oil. Cardiovasc Res 2007 Jan 15; 73 (2): 316-25. https://www.ncbi.nlm.nih.gov/pubmed/16859661, accessed on: May 3, 2019.

DiNicolantonio, J.J. et al. (2013): L-carnitine in the secondary prevention of cardiovascular disease: a systematic review and meta-analysis. Mayo Clin Proc 2013 Jun; 88 (6): 544-51. https://www.ncbi.nlm.nih.gov/pubmed/23597877/, accessed on: 03.05.2019

Endo, T. et al. (2014): Los serum eicosapentaenoic acid level is a risk for ventricular arrhythmia in patients with acute myocardial infarction: a possible link to J-waves. Heart Vessels 2014 Nov; 29 (6): 847-54. https://www.ncbi.nlm.nih.gov/pubmed/24212260, accessed on: May 3, 2019.

Eslami, M. et al. (2007): Oral ascorbic acid in combination with beta-blockers is more effective than beta-blockers alone in the prevention of atrial fibrillation after coronary bypass grafting. Tex Heart Inst J 2007; 34 (3): 268-274. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995047/, accessed on: May 3, 2019.

Ferrari, R. et al. (2004): Therapeutic effects of L-Carnitine and propionyl-L-carnitine and propionyl-L-carnitine on cardiovascular disease: a review. Ann N Y Acad Sci 2004 Nov; 1033: 79-91. https://www.ncbi.nlm.nih.gov/pubmed/15591005, accessed on: May 3, 2019.

Goel, A. et al. (2018): Fish, Fish Oils and Cardioprotection: Promise or Fish Tale? Int J Mol Sci 2018 Nov 22; 19 (12). https://www.ncbi.nlm.nih.gov/pubmed/30469489, accessed on: May 3, 2019.

Gröber, U. (2011): Micronutrients. Metabolic Tuning - Prevention - Therapy. 3rd edition. Wissenschaftliche Verlagsgesellschaft mbH Stuttgart.

Gröber, U. (2018): Drugs and Micronutrients - Medication-Oriented Supplementation. 4th edition. Wissenschaftliche Verlagsgesellschaft Stuttgart.

Horner, S.M. (1992): Efficacy of intravenous magnesium in acute myocardial infarction in reducing arrhythmias and mortality. Meta-analysis of magnesium in acute myocardial infarction. Circulation 1992 Sep; 86 (3): 774-9. https://www.ncbi.nlm.nih.gov/pubmed/1387591, accessed on: May 3, 2019.

Kones, R. et al. (2018): n-3 polyunsaturated fatty acids and cardiovascular disease: principles, practices, pitfalls, and promises - a contemporary review. Med Princ Pract 2018 Feb; 26 (6): 497-508. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848472/, accessed on: May 3, 2019.

Leon, H. et al. (2008): Effect of fish oil on arrhythmias and mortality: systematic review. BMJ 2008; 337: a2931. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612582/, accessed on: May 3, 2019.

Manor, O. et al. (2018): A multi-omic association study of trimethylamine n-oxide. Cell Rep 2018 Jul 24; 24 (4): 935-946. https://www.ncbi.nlm.nih.gov/pubmed/30044989, accessed on: May 3, 2019.

Martina, B. et al. (1992): Anti-arrhythmia treatment using L-carnitine in acute myocardial infarct. Switzerland Med Wochenschr 1992 Sep 12; 122 (37): 1352-5. https://www.ncbi.nlm.nih.gov/pubmed/1384117, accessed on: May 3, 2019.

Mondillo, S. et al. (1995): Therapy of arrhythmia induced by myocardial ischemia. Association of L-carnitine, propafenone and mexiletine. Clin Ter 1995 Dec; 146 (12): 769-74. https://www.ncbi.nlm.nih.gov/pubmed/8681496, accessed on: May 3, 2019.

Mortensen, A.L. (2019): Effect of coenzyme Q10 in Europeans with chronic heart failure: A sub-group analysis of the Q-SYMBIO randomized double-blind trial. Cardiol J 2019; 26 (2): 147-56. https://journals.viamedica.pl/cardiology_journal/article/view/CJ.a2019.0022/47605, accessed on: May 3, 2019.

Mozaffarian, D. et al. (2004): Fish intake and risk of incident atrial fibrillation. Circulation 2004 Jul 27; 110 (4): 368-73. https://www.ncbi.nlm.nih.gov/pubmed/15262826, accessed on: 03.05.20019.

Najafi, M. et al. (2008): Antiarrhythmic and arrhythmogenic effects of L-carnitine in ischemia and reperfusion. Bull Exp Biol Med 2008 Aug; 146 (2): 210-3. https://www.ncbi.nlm.nih.gov/pubmed/19145320, accessed on: May 3, 2019.

Najafi, M. et al. (2014): Short term administration of L-carnitine can be detrimental to the ischemic heart. Adv Pharm Bull 2014; 4 (1): 1-3. https://www.ncbi.nlm.nih.gov/pubmed/24409402, accessed on: May 3, 2019.

Niimi, N. et al. (2016): Involvement of oxidative stress and impaired lysosomal degradation in amiodorane-induced schwannopathy. Eur J Neurosci. 2016 Jul; 44 (1): 1723-33. https://www.ncbi.nlm.nih.gov/pubmed/27152884, accessed on: May 3, 2019.

Palazzuoli, V. et al. (1993): The evaluation of the antiarrhythmic activity of L-carnitine and propafenone in ischemic cardiopathy. Clin Ter 1993 Feb; 142 (2): 155-9. https://www.ncbi.nlm.nih.gov/pubmed/7682488, accessed on: May 3, 2019.

Raitt, M.H. et al. (2005): Fish oil supplementation and risk of ventricular tachycardia and ventricular fibrillation in patients with implantable defibrillators: a randomized controlled trial. JAMA 2005 Jun 15; 293 (23): 2884-91. https://www.ncbi.nlm.nih.gov/pubmed/15956633, accessed on: May 3, 2019.

Rizzon, P. et al. (1989): High doses of L-carnitine in acute myocardial infarction: metabolic and antiarrhythmic effects. Eur Heart J 1989 Jun; 10 (6): 502-8. https://www.ncbi.nlm.nih.gov/pubmed/2668006, accessed on: May 3, 2019.

Salaminia, S. (2018): Evaluating the effect of magnesium supplementation and cardiac arrhythmias after acute coronary syndrome: a systematic review and meta-analysis. BMC 2018, 18 (1): 129. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025730/, accessed on: May 3, 2019.

Schlimpert, V. (2018): Special "fish oil" preparation amazes with sensational results for heart protection. Doctors newspaper online, November 12, 2018. https://www.aerztezeitung.de/medizin/krankheiten/herzkreislauf/herzinfarkt/article/975781/ausnahmestudie-reduce-it-vorstellungs-herzschutz-effekt-durch-spezielle-fischoel-kapseln.html, accessed on: 03.05.2019 .

Shan, Z. et al. (2017): Association between microbiota-dependent metabolite trimethylamine-n-oxide and type 2 diabetes. Am J Clin Nutr 2017 Sep; 106 (3): 888-894. https://www.ncbi.nlm.nih.gov/pubmed/28724646, accessed on: May 3, 2019.

Shang, R. et al. (2014): Effective dosing of L-carnitine in the secondary prevention of cardiovascular disease: a systematic review and meta-analysis. BMC Cardiovasc Disord 2014 Jul 21; 14:88. https://www.ncbi.nlm.nih.gov/pubmed/25044037, accessed on: May 3, 2019.

Shiga, T. et al. (2004): Magnesium prophylaxis for arrhythmias after cardiac surgery: a meta-analysis of randomized controlled trials. Am J Med 2004 Sep 1; 117 (5): 325-33. https://www.ncbi.nlm.nih.gov/pubmed/15336582, accessed on: May 3, 2019.

Singh, R.B. et al. (1998): Randomized, double-blind placebo-controlled trial of coenzyme Q10 in patients with acute myocardial infarction. Cardiovasc Drugs Ther 1998 Sep; 12 (4): 347-53. https://www.ncbi.nlm.nih.gov/pubmed/9825179, accessed on: May 3, 2019.

Tang, W.H. et al. (2017): Increased trimethylamine n-oxide portends high mortality risk independent of glycemic control in patients with type 2 diabetes mellitus. Clin Chem 2017 Jan; 63 (1): 297-306. https://www.ncbi.nlm.nih.gov/pubmed/27864387, accessed on: May 3, 2019.

Wang, Z.Y. et al. (2018): I-Carnitine and heart disease. Life Sci 2018 Feb 1; 194: 88-97. https://www.ncbi.nlm.nih.gov/pubmed/29241711, accessed on: May 3, 2019.

Weir, M.R. et al. (2015): Clinical perspectives on the rationale for potassium supplementation. Postgrad Med 2015 Jun; 127 (5): 539-48. https://www.ncbi.nlm.nih.gov/pubmed/25960118, accessed on: May 3, 2019.

Weisman, D. et al. (2017): Effect of supplemented intake of omega-3 fatty acids on arrhythmic patients with ICD: fish oil therapy may reduce ventricular arrhythmia. J Interv Card Electrophysiol 2017 Sep; 49 (3): 255-261. https://www.ncbi.nlm.nih.gov/pubmed/28664342, accessed on: May 3, 2019.

Wirell, M.P. et al. (1994): Nutritional dose of magnesium in hypertensive patients on beta blockers lowers systolic blood pressure: a double-blind, cross-over study. J Intern Med 1994 Aug; 236 (2): 189-95. https://www.ncbi.nlm.nih.gov/pubmed/7913949, accessed on: May 3, 2019.

Zaki, M.S. et al. (2009): Role of vitamin-E on rat liver-amiodarone: an ultrastructural study. Saudi J Gastroenterol 2009 Apr; 15 (2): 104-110. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702968/, accessed on: May 3, 2019.

Zhao, Q. et al. (2015): Effect of coenzyme Q10 on the incidence of atrial fibrillation in patients with heart failure. J Investig Med 2015 Jun; 63 (5): 735-9. https://www.ncbi.nlm.nih.gov/pubmed/25919281, accessed on: May 3, 2019.