What drugs are anticholinergic antidepressants
When drugs cloud the mind
Harry Sander, the pensioner* Since the death of his wife, he has been behaving strangely: he no longer knows how to make coffee and can no longer find the way to the bus stop by himself. His son suspects that it is beginning dementia and takes the father to the memory clinic in Hanover. "The 70-year-old had significant memory gaps", remembers the geriatrician Dr. Olaf Krause from the Medical University of Hanover."But if older people are confused, it can often be the result of certain drugs, for example those with anticholinergic agents."
Drugs cause memory lapses
The geriatrician asked the pensioner whether and which medication he was taking regularly. And Sander actually pulled an antidepressant with anticholinergic effects out of his toiletry bag. His family doctor had prescribed this for him after his wife's death. "We then stopped the drug and after a week the patient was clear in his head and had normal memory function"says Krause."But the connection is not always that clear and the patient does not always recover so well when the drug is discontinued."
Anticholinergics are found in many drugs
Anticholinergic effects have been described for more than 600 drugs. They suppress the action of the messenger substance acetylcholine and - to put it simply - act on the interaction of muscles and nerves. Anticholinergic effects can be desired therapeutically, but they can also occur as undesirable side effects. They are used therapeutically in Parkinson's drugs, drugs against nausea or incontinence. As an undesirable side effect, anticholinergic effects occur e.g. with tricyclic antidepressants or anti-allergy tablets.
Do nerve cells die?
In any case, caution is advised when handling anticholinergics, as a study by Canadian researcher Shannon Risacher has now shown. Her research group has shown that older people who took drugs with strong anticholinergic effects did worse in cognition tests than a comparison group and also had lower brain activity and brain volume. A causal connection between the active ingredients and nerve cell damage has not yet been proven.
Elderly people in particular are at risk
It has long been known that older people in particular are sensitive to anticholinergic agents. Nevertheless, the drugs are widely used: almost 40 percent of those over 75 who live at home take anticholinergics. Aging physicians such as the dementia specialist Prof. Klaus Hager from the Diakovere Henriettenstift Hannover advocate more careful handling when prescribing such substances. "For us this is our daily bread - if we look through people's list of medicines, we always find unsuitable medicines among them."- The risk groups for anticholinergic side effects include elderly people who take psychotropic drugs, patients with Parkinson's disease and those with dementia.
Also be careful with over-the-counter drugs
"It becomes particularly problematic when patients also get over-the-counter medication from the pharmacy"warns the specialist pharmacist for geriatric pharmacy Dr. Beate Wickop from the University Medical Center Hamburg-Eppendorf. Because even over-the-counter items can contain anticholinergic agents."The effects add up, which is particularly risky."She advises you to bring a list of all medications you have taken with you every time you visit the doctor or pharmacy.
* Name changed by the editor
- Do I need life insurance?
- What is resolution 2428 in the United Nations Security Council
- Has the Thames ever frozen over?
- Should the FBI investigate the Kavanaugh hearing
- Why was the Bitcoin Community against bigger blocks
- How religious should I be
- When is the PPE test for class 10
- Is life an optimization problem
- Is Allah SWT a woman
- Is math in civil engineering easy
- You can bleach your teeth with bleach
- What is an isosceles trapeze
- Why do massive stars become supernovae?
- Why doesn't chickenpox happen twice?
- Why do most NoSQL databases not support LDAP?
- What is the Senior Nutrition Program
- What does job cost cost
- How was a childhood in ancient Rome
- What pressure is required to liquefy air
- Why are games called video games
- How many vehicles run on fuel
- Why was old Nepal so rich
- There is no middle class in Bihar
- Why do plant cells need a cell
- Daeumelinchen is a Disney film
- Can light or energy be black
- Why does Bitcoin have such a high kurtosis
- Do we still need our land
- What are neo-reactionaries
- Is it depressing to be a lawyer?
- What is simmering heat used for?
- What is the reciprocal of 1 9
- Should a startup model grow before launch